Ginsenoside Rg6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

人参皂苷Rg6抑制人淋巴瘤JK细胞增殖并诱导凋亡

Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells(In Vitro):Ginsenoside Rg6 may inhibit the proliferation and induce apoptosis of human lymphoma JK cells through mitochondrial dysfunction and increased Bax expression and decreased Bcl-2 expression. In addition, ginsenoside Rg6 can also inhibit the transcriptional activity of NF-κB induced by TNF-α in SK-Hep1 cells with IC50 of 25uM.

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC50, the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM.

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Apoptosis

Apoptosis

Apoptosis

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147419-93-0

767.01

C42H70O12

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (130.38 mM)

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(-20℃)

With Ice Pack

≥ 2 years