BR102910?

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

4-噻唑甲酰胺，N-[2-[(2S)-2-氰基-4,4-二氟-1-吡咯烷基]-2-氧代乙基]-2-[(3,4-二氯苯基)甲基]-(BR102910)是成纤维细胞激活蛋白（FAP）的选择性抑制剂。

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-(BR102910) is a selective inhibitor of fibroblast activated protein (FAP).(In Vivo):4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-(C57BL/6J mice, 0-30 mg/kg, orally, once) showed significant FAP inhibition in a dose dependent manner .

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BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner. Animal Model:C57BL/6J mice (n = 5 per group)Dosage:0, 10 and 30 mg/kg Administration:Orally, once Result:Showed significant FAP inhibition in a dose dependent manner.

4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-

Others

Other Targets

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2505339-54-6

459.3

C18H14Cl2F2N4O2S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (217.72 mM)

O=C(C1=CSC(CC2=CC=C(Cl)C(Cl)=C2)=N1)NCC(N3[C@@H](C#N)CC(F)(F)C3)=O

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(-20℃)

With Ice Pack

≥ 2 years