Manganese(salen) chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氯化锰 (Salen) (EUK-8) 是一种超氧化物歧化酶和过氧化氢酶模拟物，是一种具有氧自由基清除特性的抗氧化剂。氯化锰（萨伦）可改善内毒素血症猪的急性肺损伤。

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.(In Vitro):Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation. (In Vivo):Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant . Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation.

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. Animal Model:Wild-type (WT) and harlequin (Hq) B6CBA male and female mice Dosage:25 mg/kg/day Administration:I.p. 3 times a week for 4 weeksResult:Prevented myocardial oxidant damage provoked by biomechanical stress.Improved survival following biomechanical stress.Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

EUK-8

Others

Other Targets

monophenolase

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53177-12-1

356.69

C16H14ClMnN2O2

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (23.35 mM)

[Cl-].[Mn+5].[O-]c1ccccc1\C=[N-]\CC\[N-]=C/c1ccccc1[O-]

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(-20℃)

With Ice Pack

≥ 2 years