NH-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NH-3 是一种口服活性、可逆性甲状腺激素受体 (THR) 拮抗剂，IC 50 为 55 nM。 NH-3 是选择性促甲状腺激素 GC-1 的衍生物，可抑制甲状腺激素与其受体的结合，并抑制辅助因子的募集。

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.(In Vivo):NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose .

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Endocrinology/Hormones

THR

Na+/Ca2+ Exchanger

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447415-26-1

473.52

C28H27NO6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (211.18 mM)

CC(C)C1=CC(CC2=C(C)C=C(OCC(O)=O)C=C2C)=CC(C#CC2=CC=C(C=C2)[N+]([O-])=O)=C1O

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(-20℃)

With Ice Pack

≥ 2 years