Eprotirome ( KB2115 )

产品货号. M20098 CAS No. 355129-15-6

Eprotirome 是一种合成的甲状腺激素模拟物，是一种甲状腺激素受体激动剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥283	有现货
10MG	￥449	有现货
25MG	￥882	有现货
50MG	￥1386	有现货
100MG	￥2151	有现货
200MG	￥3024	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Eprotirome
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Eprotirome 是一种合成的甲状腺激素模拟物，是一种甲状腺激素受体激动剂。
产品描述

Eprotirome a synthetic thyroid hormone mimetic is a thyroid hormone receptor agonist.(In Vivo):Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.
体外实验

——
体内实验

Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.
同义词

KB2115
通路

Endocrinology/Hormones
靶点

THR
受体

THR
研究领域

Metabolic Disease
适应症

Dyslipidaemias; Hypercholesterolaemia; Obesity

化学信息

CAS Number

355129-15-6
分子量

487.14
分子式

C18H17Br2NO5
纯度

>98% (HPLC)
溶解度

DMSO: 90 mg/mL (184.75 mM);Ethanol: 30 mg/mL
SMILES

CC(C)c1cc(Oc2c(Br)cc(NC(=O)CC(O)=O)cc2Br)ccc1O
化学全称

3-((35-Dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Berkenstam A et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):663-7.

计算器

浓度计算器

摩尔计算器

分子量计算器

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