Fumaric acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

富马酸通过抑制 p38 MAPK 依赖性 NF-κB 信号传导来减弱 TNF-α 刺激的成纤维细胞中 eotaxin-1 的表达。

Fumaric acid is a dicarboxylic acid. It is a oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes.

Western Blot Analysis Cell Line:NIH/3T3 Concentration:50 μM Incubation Time:24 h Result:Inhibited p38 MAPK and IκB-a phosphorylation.Attenuated TNF-a-induced NF-κB and decreased the expression of CCR3. Reduced the NF-κB activation induced by TRADD, TRAF2, and MEKK3.

Animal Model:Gestational hypertension rat modelDosage:10 mL/kg Administration:i.v.Result:Downregulated the levels of TET1 and KCNMB1.

Fumaric acid | Kyselina fumarova | Lichenic acid

Endocrinology/Hormones

THR

Others

——

——

110-17-8

116.1

C4H4O4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (215.39 mM)

C(=C/C(=O)O)\C(=O)O

2-Butenedioic acid (2E)-

(-20℃)

With Ice Pack

≥ 2 years