N-Desalkylflurazepam

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-去烷基氟西泮（去甲氟西泮）是苯二氮卓类化合物（如氟西泮）的长效代谢物。 N-Desalkylflurazepam 抑制 L 型电压门控钙通道，Ca v 1.2 和 Ca v 1.3 的 IC 50 值分别为 55 μM 和 37 μM。

N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.(In Vitro):Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components .

Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components.

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Norfludiazepam

GPCR/G Protein

Calcium Channel

S-adenosylmethionine decarboxylase (SAMDC)

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2886-65-9

288.71

C15H10ClFN2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (346.38 mM)

Fc1ccccc1C1=NCC(=O)Nc2ccc(Cl)cc12

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(-20℃)

With Ice Pack

≥ 2 years