GV-58 ( GV58 )

产品货号. M11683 CAS No. 1402821-41-3

GV-58 是一种有效的选择性 N 型和 P/Q 型 Ca2+ 通道激动剂，EC50 分别为 7.2 和 8.8 uM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1378	有现货
10MG	￥2071	有现货
25MG	￥3469	有现货
50MG	￥5003	有现货
100MG	￥6732	有现货
200MG	￥8883	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥1131	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

GV-58
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GV-58 是一种有效的选择性 N 型和 P/Q 型 Ca2+ 通道激动剂，EC50 分别为 7.2 和 8.8 uM。
产品描述

GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM); has 20-fold less potent cyclin-dependent kinase antagonist effect; slows deactivation (closing) of the channel, resulting in a large increase in total calcium entry during motor nerve action potential activity; weakens Lambert-Eaton myasthenic syndrome-model neuromuscular synapses in a passive transfer mouse model of Lambert-Eaton myasthenic syndrome.
体外实验

GV-58 (50 μM; 30 min) restores function in LEMS passive transfer neuromuscular junction. Cell Viability Assay Cell Line:Upper arm muscle isolated from LEMS mice Concentration:50 μM Incubation Time:30 min Result:Increased the mEPP frequency from 3.27 s?1 in vehicle controls to 10.45 s?1. Showed a slight facilitation followed by depression to ～94% at the final EPP in the train.
体内实验

——
同义词

GV58
通路

GPCR/G Protein
靶点

Calcium Channel
受体

Calcium Channel
研究领域

Neurological Disease
适应症

——

化学信息

CAS Number

1402821-41-3
分子量

374.5036
分子式

C18H26N6OS
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CCCN1C=NC2=C(N=C(N=C21)NC(CC)CO)NCC3=CC=C(S3)C
化学全称

1-Butanol, 2-[[6-[[(5-methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Tarr TB, et al. Ann N Y Acad Sci. 2012 Dec;1275:85-91. 2. Tarr TB, et al. J Neurosci. 2013 Jun 19;33(25):10559-67. 3. Tarr TB, et al. J Physiol. 2014 Aug 15;592(16):3687-96. 4. Liang M, et al. ACS Med Chem Lett. 2012 Oct 1;3(12):985-90.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册

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