3-Phenyltoxoflavin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-Phenyltoxoflavin 是 HSP90 的抑制剂 (Kd = 585 nM)，具有抗癌活性。

3-Phenyltoxoflavin is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.(In Vitro):3-Phenyltoxoflavin (0.56 nM-100 μM) dose-dependently competes with biotinylated Hsp90 peptide for binding to TPR2A. In BT474 cells, 3-Phenyltoxoflavin (1 nM-100 μM) dose-dependently inhibits cell proliferation with an IC50 of 690 nM.

3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM.3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner.

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ZINC267655 | Phenyltoxoflavin

Cytoskeleton/Cell Adhesion Molecules

HSP

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32502-63-9

269.26

C13H11N5O2

>98% (HPLC)

In Vitro:?DMSO : 7.14 mg/mL (26.52 mM)

O=C1N=C2C(=NC(=NN2C)C3=CC=CC=C3)C(=O)N1C

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(-20℃)

With Ice Pack

≥ 2 years