Ponicidin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ponicidin 是一种从冬凌草中提取的二萜类化合物。 Ponicidin 具有免疫调节、抗炎、抗病毒和抗癌活性。

Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma cells, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.(In Vitro):K562 cells in culture medium in vitro were given different concentrations of Ponicidin (10-50 micromol x L(-1)) for 24, 48, and 72 h. The inhibitory rate of the cells was measured by MTT assay, cell apoptotic rates were detected by flow cytometry (FCM) using Annexin V staining after K562 cells were treated with different concentrations of Ponicidin for 72 hours, and cell morphology was observed by Wright-Giemsa staining. Ponicidin (over 30 micromol x L(-1)) could inhibit the growth of K562 cells in both time- and dose-dependent manner. FCM analysis revealed that apoptotic cells were gradually increased in a dose-dependent manner after treatment for 72 hours, and that marked morphological changes of cell apoptosis such as condensation of chromatin was clearly observed by Wright-Giemsa staining after treatment by 50 micromol x L(-1) Ponicidin. Furthermore, Western blotting also showed that expression of p-AKT and p-P85 in PI3K/AKT signaling pathways was downregulated dramatically whereas the expression of p-P38, as well as p-ERK and p-JNK, remained unchanged after the cells were treated by PON for 48 h.

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Rubescensine B

Apoptosis

Apoptosis

EGFR|HER2

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52617-37-5

362.42

C20H26O6

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (344.90 mM)

C=C1C([C@@]23[C@](O)(O4)[C@@H](O)[C@]5([H])C(C)(C)CC[C@H](O)[C@@]5([C@@]4([H])O[C@@]3([H])[C@H]1CC6)[C@@]26[H])=O

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(-20℃)

With Ice Pack

≥ 2 years