Jolkinolide B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Jolkinolide B 是一种从大戟 (Euphorbia fischeriana Steud) 根中分离出来的生物活性二萜。 Jolkinolide B 诱导癌细胞凋亡。 Jolkinolide B 可用于预防和治疗骨溶解的研究。

Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.(In Vitro):Jolkinolide B has potent anti-inflammatory, and antitumor activities. Jolkinolide B is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B inhibited RANKL-induced osteoclast differentiation from bone marrow macrophages (BMMs) without cytotoxicity. Furthermore, the expression of osteoclastic marker genes, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K (CtsK), and calcitonin receptor (CTR), was significantly inhibited. Jolkinolide Binhibited RANKL-induced activation of NF-?oB by suppressing RANKL-mediated I?oBα degradation. Moreover, Jolkinolide B inhibited RANKL-induced phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK).

——

——

——

Apoptosis

PERK

Leishmania tropica

——

——

37905-08-1

330.42

C20H26O4

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (25.21 mM)

CC1=C2[C@H]3O[C@]33CC[C@@H]4C(C)(C)CCC[C@@]4(C)C3[C@H]3O[C@@]23OC1=O

——

(-20℃)

With Ice Pack

≥ 2 years