rac-BHFF

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rac-BHFF 是有效且选择性的 GABA B 受体正变构调节剂，可提高 GABA 的效力和功效（分别 > 15 倍和 > 149%）。

Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active.

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rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice.rac-BHFF (3, 10, 30 and 100?mg/kg, p.o.) reverses SIH and high significance was reached for 100?mg?kg?1 (P<0.001). Animal Model:Male NMRI mice (20-25?g).Dosage:3, 10, 30 or 100 mg/kg.Administration:P.O..Result:Significantly increased the LRR effects of a subthreshold dose of baclofen at doses of 3?mg/kg and above.

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Apoptosis

PERK

GABAB

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123557-91-5

330.34

C17H21F3O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (302.72 mM)

CC(C)(C)c1cc(c2c(c1)C(C(=O)O2)(C(F)(F)F)O)C(C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years