Bufarenogin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bufarenogin 是从古巴特有蟾蜍 Peltophryne fustiger 的腮腺分泌物中分离出来的蟾蜍二烯内酯。蟾蜍皂苷具有抗肿瘤活性。

Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity.(In Vitro):Bufarenogin caused cell death via apoptosis. Bufarenogin induced B-cell lymphoma 2-associated X protein (Bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of Bax and cytoplasm release of HCT116 wild-type cells and cytochrome C. Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells.

Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine‐nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells.

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3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide

Apoptosis

PERK

ERK

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17008-65-0

416.514

C24H32O6

>98% (HPLC)

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[H][C@]12CC[C@]3([H])[C@]([H])(C(=O)[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2

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(-20℃)

With Ice Pack

≥ 2 years