Diprotin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。

Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

Western Blot Analysis Cell Line:Human endothelial cells Concentration:100?μM Incubation Time:30?minutes after CXCR4-blocker or Src-inhibitor treatment Result:Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.

Animal Model:Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice Dosage:70?μg/kg Administration:Intraperitoneal injection; twice daily; 7 days Result:Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.

Ile-Pro-Ile

Metabolic Enzyme/Protease

DPP

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90614-48-5

341.452

C17H31N3O4

>98% (HPLC)

In Vitro:?H2O : ≥ 100 mg/mL (292.87 mM))

CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years