Sulindac sulfone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

舒林酸砜是非甾体类抗炎药舒林酸的代谢产物。 Sulindac sulfone 是一种醛糖还原酶抑制剂 (IC50 =367 nM)。

Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).(In Vitro):At 100 microMol of Sulindac sulfone, a decrease in beta-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted beta-catenin. (In Vivo):After 31 weeks of Sulindac sulfone (500-2000 ppm) treatment, a dose-related increase in Sulindac sulfone levels in both serum and cecal contents was measured; there was no evidence of metabolic conversion to sulindac or other metabolites. Rats treated with Sulindac sulfone at 1000 and 2000 ppm, sulindac, and piroxicam had significantly fewer colonic adenomas and carcinomas compared with rats fed control diet as measured by tumor incidence, multiplicity, and tumor burden. Sulindac sulfone-treated rats also showed a dose-response relationship for inhibiting all tumor parameters.

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Endocrinology/Hormones

Reductase

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59864-04-9

372.41

C20H17FO4S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (268.52 mM)

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C\c1ccc(cc1)S(C)(=O)=O

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(-20℃)

With Ice Pack

≥ 2 years