Ononetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ononetin 是一种 TRPM3 通道阻断剂 (IC50: 0.3 μM)。

Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).(In Vitro):Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones.(In Vivo):Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms.

Ononetin (1-10 μM) completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones, indicating biological activity towards endogenously expressed TRPM3.Oxidative intermediates of Ononetin may be involved in activating TRPA1, but not in the block of TRPM3 by Ononetin.

Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain.

2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Membrane Transporter/Ion Channel

TRP/TRPV Channel

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487-49-0

258.273

C15H14O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (387.19 mM)

COc1ccc(CC(=O)c2ccc(O)cc2O)cc1

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(-20℃)

With Ice Pack

≥ 2 years