Olvanil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Olvanil 是一种香草酸受体激动剂，EC50 为 0.7nM。

Olvanil is a vanilloid receptor agonist with EC50 of 0.7nM.(In Vitro):Olvanil affects C6 glioma cell proliferation with IC50 of 5.5 μM.(In Vivo):Olvanil is one capsaicin analog. Olvanil acts as an agonist at the vanilloid receptor. Olvanil may have causes an anxiogenic-like effect. Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0.

Olvanil affects C6 glioma cell proliferation (IC50?value of 5.5 μM) .

Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor.?Olvanil may have causes an anxiogenic-like effect.?Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0. Animal Model:Sprague-Dawley rats weighing approximately 200 g Dosage:0, 0.2, 1.0 and 5.0 mg/kg Administration:Injected intraperitoneally 30 min before the behavioral tests Result:The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose. The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.?

N-Vanillyloleamide | N-Vannilyloleoylamide

Membrane Transporter/Ion Channel

TRP/TRPV Channel

HDAC

——

——

58493-49-5

417.634

C26H43NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (239.45 mM)

CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1

——

(-20℃)

With Ice Pack

≥ 2 years