AM404

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AM404 是一种内源性大麻素再摄取抑制剂，可阻断 anandamide 转运，IC50 值在低微摩尔范围。去氧肾上腺素使大鼠离体肝动脉收缩，AM404 可使其放松，pEC50 值为 7.4 (对应的 EC50 值为 0.04 μM)。具有神经保护作用[ 2]。

AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Neuroprotective Effect.

AM404 reduces C6 glioma cell proliferation with IC50 values of 4.9 μM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide.Cell Viability Assay Cell Line:Rat C6 glioma cells Concentration:1, 3, 10 and 30 μM Incubation Time:24, 48, 72 and 96 h Result:Produced a concentration-dependent reduction in cell proliferation that was seen with 24 h of exposure to 10 and 30 μM concentrations and after 48 h at 3 μM. The lowest concentration of AM404 tested, 1 μM, produced a significant, albeit small, reduction in cell proliferation at 72 h.

AM404 (1-5?mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations.Animal Model:Adult male Sprague-Dawley rats (250-300?g) Dosage:2.5-10?mg/kg Administration:Intraperitoneal (i.p.)Result:Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRP/TRPV Channel | Cannabinoid Receptor

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183718-77-6

395.58

C26H37NO2

>98% (HPLC)

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N(C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC=C(O)C=C1

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(-20℃)

With Ice Pack

≥ 2 years