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Tropisetron
CAS No. 89565-68-4
Tropisetron ( ICS 205-930 | Tropisetronum | Tropisteron )
产品货号. M27585 CAS No. 89565-68-4
Tropisetron 是一种 α7-烟碱受体激动剂和 5-HT3 受体拮抗剂，Kis 分别为 6.9 nM 和 5.3 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥242 | 有现货 |
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| 10MG | ￥373 | 有现货 |
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| 25MG | ￥547 | 有现货 |
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| 50MG | ￥849 | 有现货 |
|
| 100MG | ￥1287 | 有现货 |
|
| 500MG | ￥3222 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥258 | 有现货 |
|
生物学信息
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产品名称Tropisetron
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tropisetron 是一种 α7-烟碱受体激动剂和 5-HT3 受体拮抗剂，Kis 分别为 6.9 nM 和 5.3 nM。
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产品描述Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.(In Vitro):The IC50 value of Tropisetron for the 5-HT3 receptor is 70.1 ± 0.9 nM. Tropisetron inhibits IL-2 production and antigen-induced proliferation in human peripheral T cells and inhibits signaling pathways that regulate the activation of transcription factors AP-1, NFAT, and NF-κB.(In Vivo):Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity.
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体外实验——
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体内实验——
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同义词ICS 205-930 | Tropisetronum | Tropisteron
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体TRPM8
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研究领域——
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适应症——
化学信息
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CAS Number89565-68-4
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分子量284.359
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分子式C17H20N2O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837.
产品手册
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