CBFβ Inhibitor ( 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine )

产品货号. M27517 CAS No. 493028-20-9

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HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CBFβ Inhibitor
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CBFβ Inhibitor 是一种细胞渗透性 CBFβ 抑制剂，可抑制其与 Runx1 的关联。
产品描述

CBFβ Inhibitor is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.(In Vitro):The ELISA results have shown that CBFβ Inhibitor is very effective in inhibiting the CBFβ-Runx1 interaction (IC50: 3.2 μM). In the leukemia cell line ME-1 expressing CBFβ-SMMHC, CBFβ Inhibitor reduced cell proliferation dose-dependently. Treatment with CBFβ Inhibitor for 3 days showed an increase in apoptotic cells. Treatment with CBFβ Inhibitor for 14 days individually or with all-trans-retinoic acid (ATRA) resulted in cells with greater variation in size and shape, lower nuclear-to-cytoplasmic ratio, increased folding, and lobation of nuclei, and more clumped chromatin. All of these morphology changes are consistent with differentiation to more mature forms. CBFβ Inhibitor at 50 μM increased proliferation of Hep-G2 cells. CBFβ treatment with Inhibitor resulted in a statistically significant reduction in Runx1 bound to DNA .
体外实验

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体内实验

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同义词

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
通路

Cell Cycle/DNA Damage
靶点

DNA/RNA Synthesis
受体

Cleavable
研究领域

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适应症

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1.Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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