HALOFUGINONE LACTATE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物，febrifugine 是一种天然的含有喹唑啉酮的化合物，存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶，Ki 为 18.3 nM。 Halofuginone (HF) 是一种广泛研究的常量衍生物，可抑制小鼠 T(H)17 驱动的自身免疫的发展通过激活氨基酸反应（AAR）途径建立多发性硬化症模型。 HF 结合谷氨酰-脯氨酰-tRNA 合成酶（EPRS），抑制脯氨酰-tRNA 合成酶活性；通过添加外源脯氨酸或 EPRS 可以逆转这种抑制作用。

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM.?Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS.

——

——

——

Cell Cycle/DNA Damage

DNA/RNA Synthesis

prolyl-tRNA synthetase|TGF-β

Others

Duchenne muscular dystrophy

82186-71-8

504.8

C19H23BrClN3O6

>98% (HPLC)

——

CC(O)C(O)=O.O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3

——

(-20℃)

With Ice Pack

≥ 2 years