NS3694

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NS3694 是一种细胞凋亡抑制剂，可抑制凋亡体形成和 caspase 激活。

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.(In Vitro):NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis.

When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed.NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. Western Blot Analysis Cell Line:HeLa cells Concentration:10 μM, 50 μM, 100 μM Incubation Time:120 min Result:Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.

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Apoptosis

Apoptosis

non-cleavable ADC linker|Alkyl-Chain

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426834-38-0

358.7

C15H10ClF3N2O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (696.96 mM)

O=C(O)C1=CC=C(Cl)C=C1NC(=O)NC2=CC=CC(=C2)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years