Terameprocol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Terameprocol 是一种合成的去甲二氢愈创木酸 (NDGA) 四甲基化衍生物和转录抑制剂，具有潜在的抗病毒、抗血管生成和抗肿瘤活性。 Terameprocol 显示出最强的抗 HIV 活性。

Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.(In Vitro):In Vero cells, Terameprocol inhibited Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter with IC50 values of 11 and 43.5 μM, respectively. The IC50 of Terameprocol varied between 11.7 and 4 μM in 10 passages of HSV-1 and 4 passages of HSV-2 . Terameprocol inhibited Sp1-dependent Cdc2 gene expression. In M4N-treated transformed C3 cells, Terameprocol induced growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity . Terameprocol treatment suppressed expression of the Sp1-dependent survivin gene. In transiently and stably survivin-transfected C3 cells, Terameprocol reduced caspase-3 activation by 50% and 75%, respectively . Terameprocol inhibited the growth of a number of tumor cell lines by inducing apoptosis in a non-schedule-dependent manner . Terameprocol inhibited the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle .(In Vivo):Terameprocol effectively inhibited the growth of human tumors in nude mice . Terameprocol inhibited the growth of both murine and human melanomas and human colon cancer without apparent hepatic or renal toxicity . In nude (nu/nu) mice bearing xenografts of human tumor types (Hep 3B, LNCaP, HT-29, MCF7, and K-562), treatment with Terameprocol (i.v. or i.p.) down-regulated Cdc2 and survivin genes expression .

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EM-1421 | tetramethyl Nordihydroguaiaretic Acid

Microbiology/Virology

HIV

IFNAR

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24150-24-1

358.478

C22H30O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (278.96 mM)

COc1ccc(CC(C)C(C)Cc2ccc(OC)c(OC)c2)cc1OC

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(-20℃)

With Ice Pack

≥ 2 years