FAUC-365

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FAUC-365 是一种 D3 多巴胺受体激动剂。

FAUC-365 is a D3 dopamine receptor agonist.(In Vitro):As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively .

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FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide

GPCR/G Protein

Dopamine Receptor

LOXL2|LOXL3

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474432-66-1

462.43

C23H25Cl2N3OS

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (72.07 mM)

Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years