Buspirone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Buspirone free base 是一种具有抗焦虑活性的血清素受体激动剂。丁螺环酮游离碱的功效与地西泮相当。

Buspirone free base is an agonist of serotonin receptor with anxiolytic activity. Buspirone free base has an efficacy comparable to diazepam.

Buspirone (0-400 μg/mL; 6 hours) has cytotoxic effect in Lymphocytes.Buspirone (0-180 μg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG). Cell Viability Assay Cell Line:Lymphocytes Concentration:0, 4, 20, 40, 200 and 400 μg/mL Incubation Time:6 hours Result:Decreased cell viability in a dose-dependent manner.

Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors.Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota. Animal Model:Male C57BL/6N mice Dosage:1 and 5 mg/kg Administration:Oral gavage and intraperitoneal injection; for 5 days Result:Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.Animal Model:Male C57BL/6N mice Dosage:1 and 5 mg/kg Administration:Oral gavage and intraperitoneal injection; for 5 days Result:Reduced the IS- or EC-induced gut Proteobacteria population.

Buspirone free base | Ansial

Endocrinology/Hormones

5-HT Receptor

EGFR (T790M)|EGFR (L858R/T790M)|EGFR (del19/T790M)

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36505-84-7

385.512

C21H31N5O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (259.40 mM)

O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1

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(-20℃)

With Ice Pack

≥ 2 years