S-23

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

S-23 是一种口服选择性雄激素受体调节剂 (SARM)，Ki 为 1.7 nM。 S-23 增加去势大鼠的前列腺、精囊和提肛肌重量。

S-23 is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.(In Vitro):Administration of 10 nM S-23 induces AR-mediated transcriptional activation in CV-1 cells .(In Vivo):Administration of S-23 to castrated animals increases the weights of the androgen-dependent organ dose-dependently with the ED50s of S-23 in the prostate and levator ani muscle of 0.43 and 0.079 mg/d, respectively.

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM.

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively. Animal Model:Male Sprague Dawley rats (in castrated male rats)Dosage:0.01-3 mg Administration:S.c.; daily for 14 d Result:Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.

S 23 | S23 | (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Endocrinology/Hormones

Androgen Receptor (AR)

PDE3

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1010396-29-8

416.76

C18H13ClF4N2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (239.95 mM)

C[C@](O)(COc1ccc(Cl)c(F)c1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years