Adrenosterone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Adrenosterone ((+)-Adrenosterone) 是一种竞争性羟基类固醇 (11-β) 脱氢酶 1 (HSD11β1) 抑制剂。

Adrenosterone is a steroid hormone with weak androgenic effect. (In Vitro):Adrenosterone markedly decreases Snail and Slug expression in HCCLM3 and MDA-MB-231 cells. Adrenosterone suppresses cell motility and invasion of highly metastatic human cancer cells (HCCLM3, MDA-MB-231, and MDA-MB-435 cells).Adrenosterone is a competitive inhibitor of HSD11β1, which catalyzes the interconversion of the steroid pair of the inactive metabolite cortisone and the stress hormone cortisol. Adrenosterone decreases the amount of cortisol.

Adrenosterone markedly decreases Snail and Slug expression in HCCLM3 and MDA-MB-231 cells. Adrenosterone suppresses cell motility and invasion of highly metastatic human cancer cells (HCCLM3, MDA-MB-231, and MDA-MB-435 cells). Adrenosterone is a competitive inhibitor of HSD11β1, which catalyzes the interconversion of the steroid pair of the inactive metabolite cortisone and the stress hormone cortisol. Adrenosterone decreases the amount of cortisol.

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Adrenosterone |

Endocrinology/Hormones

Androgen Receptor (AR)

Androgen Receptor

Endocrinology

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382-45-6

300.4

C19H24O3

>98% (HPLC)

DMSO: 10 mM

C[C@@]([C@](CC1)([H])[C@]2([H])CCC3=CC(CC[C@]3(C)[C@@]2([H])C4=O)=O)(C4)C1=O

(8S,9S,10R,13S,14S)-10,13-dimethyl-6,7,8,9,10,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,11,17(2H)-trione

(-20℃)

With Ice Pack

≥ 2 years