AMTB hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AMTB 是一种新型 TRPM8 通道阻滞剂，对疼痛和泌尿系统疾病有效。

AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat.(In Vivo):For rats, AMTB (10 mg/kg) significantly attenuated reflex responses to noxious urinary bladder distension (UBD) to 5.42 and 56.51% of the maximal visceromotor reflex (VMR) response and pressor response, respectively. The ID50 value on VMR response was 2.42 +/- 0.46 mg/kg .

AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8). AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM).

In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction.

AMTB HCl

Membrane Transporter/Ion Channel

TRP/TRPV Channel

PPARδ

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926023-82-7

430.99

C23H27ClN2O2S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (232.02 mM)

Cl.Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1

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(-20℃)

With Ice Pack

≥ 2 years