Tyrosine kinase inhibitor

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

酪氨酸激酶抑制剂是一种酪氨酸激酶抑制剂，与片段化芳香族氮化合物联合用作抗增殖剂。

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.(In Vitro):Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly regulated in normal cells, they may acquire transforming functions due to mutation(s), overexpression and autocrine paracrine stimulation, leading to malignancy. Constitutive oncogenic activation in cancer cells can be blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for innovative genome based therapeutics.

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli.

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Angiogenesis

c-Met/HGFR

Reactive Oxygen Species

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1021950-26-4

586.624

C31H31FN6O5

>98% (HPLC)

In Vitro:?DMSO : ≥ 46 mg/mL (78.42 mM)

Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)C(=O)NCCN3CCOCC3)cc2)cc1

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(-20℃)

With Ice Pack

≥ 2 years