Sorivudine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

索立夫定通过干扰病毒 DNA 合成，对多种病毒具有抗病毒活性，包括水痘带状疱疹病毒、1 型单纯疱疹病毒和 Epstein-Barr 病毒。

Sorivudine has antiviral activity against several viruses including varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus by interfering with viral DNA synthesis.(In Vitro):Sorivudine is a pyrimidine nucleoside analog with in vitro inhibitory activity against varicella zoster virus (VZV) at concentrations of 0.0001-0.004 mg/ml. Sorivudine also inhibits HSV-I replication at concentrations ranging from 0.03-0.1 mg/ml. Sorivudine inhibited strains of HSV-1 and HSV-2 (wild-type strains VR-3 and UW-268) with ID50s of 0.39 and 0.67 μM, respectively.(In Vivo):Sorivudine (12.5 mg/kg) prolonged survival in treated mice. At doses above 50 mg/kg, mortality was significantly reduced. In the varicella virus infection model in African green monkeys (Cerophthecus aethiops), Sorivudine (20 mg/kg intramuscularly or 100 mg/kg orally daily) completely prevented viremia and death.

Sorivudine (BV-araU) inhibits strains of HSV-1 and HSV-2 (wild-type strains VR-3 and UW-268) with ID50s (50% inhibitory dose) of 0.39 and 0.67 μM, respectively.Sorivudine has antiviral activity against several viruses including varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus.Sorivudine (BV-araU) is a pyrimidine nucleoside analog which has in vitro inhibitory activity against varicella zoster virus (VZV) at concentrations of 00001-0.004 mg/ml These concentrations are over 1000-fold lower than those which are required for the inhibition of VZV replication by acyclovir 3 Sorivudine also inhibits HSV-I replication at concentrations ranging from 0.03-0.1 mg/ml.

Sorivudine (BV-araU) has been evaluated in the treatment of HSV-l encephalitis when administered orally to mice. At dosages in excess of 12.5 mg/kg, survival of treated mice is prolonged. With doses in excess of 50 mg/kg, a significant decrease in mortality was achieved as we1l. A more relevant model is that of simian varicella virus infection in African green monkeys (Cerophithecus aethiops). In this system, Sorivudine therapy at dosages as low as 20 mg/kg per day given intramuscularly or 100 mg/kg per day administered orally completely protected against viremia and mortality. In the conduct of these studies, there was no evidence of neurotoxicity or abnormalities in hematology or clinical chemistries. Doses as low as 0.2 mg/kg per day were effective; however, breakthrough viremia was noted at lower dosages.

BV-araU

Cell Cycle/DNA Damage

DNA/RNA Synthesis

Analogue of amino acids

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77181-69-2

349.137

C11H13BrN2O6

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (358.03 mM)

OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)n1cc(\C=C\Br)c(=O)[nH]c1=O

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(-20℃)

With Ice Pack

≥ 2 years