Bendamustine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BendamustineHCl 是一种与 DNA 损伤相关的烷化剂，IC50 为 50 μM。

Bendamustine hydrochloride is an alkylating agent associated with DNA damage with IC50 of 50 μM.(In Vitro):Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC25s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.(In Vivo):Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.

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SDX-105

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA synthesis

Cancer

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3543-75-7

394.72

C16H21Cl2N3O2·HCl

>98% (HPLC)

Ethanol: 17 mg/mL (43.06 mM); Water: 2 mg/mL (5.06 mM); DMSO: 78 mg/mL (197.6 mM)

Cl.CN1C(CCCC(O)=O)=NC2=C1C=CC(=C2)N(CCCl)CCCl

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(-20℃)

With Ice Pack

≥ 2 years