021-51111890
购物车（）
sales@molnova.cn
RMC-4550
CAS No. 2172651-73-7
RMC-4550 ( —— )
产品货号. M26806 CAS No. 2172651-73-7
RMC-4550 是一种有效的 SHP2 变构抑制剂 (IC50: 0.583 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1492 | 有现货 |
|
| 10MG | ￥2204 | 有现货 |
|
| 25MG | ￥3469 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1644 | 有现货 |
|
生物学信息
-
产品名称RMC-4550
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述RMC-4550 是一种有效的 SHP2 变构抑制剂 (IC50: 0.583 nM)。
-
产品描述RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).(In Vitro):RMC-4550 stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide but lacks activity against the free catalytic domain of SHP2 .(In Vivo):RMC-4550 has moderate to high bioavailability and has a half-life amenable for once daily oral administration. In the EGFR-driven KYSE-520 human esophageal cancer xenograft model, RMC-4550 has a dose dependent efficacy consistent with target modulation, assessed by phospho-ERK inhibition in tumors. RMC-4550 is well tolerated at doses that achieved maximal and sustained efficacy in this model.
-
体外实验RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2.
-
体内实验——
-
同义词——
-
通路Metabolic Enzyme/Protease
-
靶点Phosphatase
-
受体S. aureus
-
研究领域——
-
适应症——
化学信息
-
CAS Number2172651-73-7
-
分子量437.37
-
分子式C21H26Cl2N4O2
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (228.64 mM)
-
SMILESC[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Jian-Ming, Shi-Chang, Sun, et al. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus.[J]. International journal of antimicrobial agents, 2018.
