NS5806

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NS5806 是一种有效的钾电流激活剂。 NS5806 减缓含有 KChIP2 的通道复合物中 KV4.3 和 KV4.2 电流的衰减。

NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).(In Vitro):NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells.

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NS-5806

Cell Cycle/DNA Damage

Potassium Channel

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426834-69-7

574.079

C16H8Br2F6N6O

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (435.49 mM)

FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c2nn[nH]n2)cc(c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years