AUT1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AUT1 (AUT-1) 是一种新颖的 Kv3 通道特异性调节剂（EC50：Kv3.1b 和 Kv3.2a 的 EC50：4.7 和 4.9 uM）。

AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).

AUT1 (1.5, 12.5, and 25 μM) modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50s of 5.33 and 5.31 μM, respectively.AUT1 increases whole currents mediated by human Kv3.1b and Kv3.2a channels in a concentration-dependent manner. AUT1 (10 and 30 μM) shifts both the voltage dependence of activation and inactivation of human Kv3.1b and Kv3.2a channels.AUT1 rescues (1 and 10 μM) the fast firing of EGFP-positive cortical interneurons.

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Cell Cycle/DNA Damage

Potassium Channel

Kv3.1b channels| Kv3.2a channels

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1311136-84-1

341.37

C18H19N3O4

>98% (HPLC)

DMSO: ≥ 250 mg/mL (732.36 mM)

CC[C@H]1NC(=O)N(C1=O)c1ccc(Oc2ccc(C)c(OC)c2)nc1

(5R)-5-Ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-24-imidazolidinedione

(-20℃)

With Ice Pack

≥ 2 years