ICA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ICA 是一种 SK 通道抑制剂，具有抗利什曼活性 (IC50：2.1 μM)。

ICA is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 μM).(In Vitro):ICA exhibited antiarrhythmic effects. ICA prevented electrically induced runs of atrial fibrillation in the isolated right atrium and induced atrial postrepolarization refractoriness and depolarized RMP. ICA (1-10 μM) was found to slow CV; however, because of a marked prolongation of effective refractory period, the calculated wavelength was increased. Furthermore, at increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrated prominent depression of other sodium channel-dependent parameters. ICA did not inhibit IK,ACh, but at concentrations above 10 μM, ICA use dependently inhibited INa.

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters.

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N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine

Cell Cycle/DNA Damage

Potassium Channel

Alkyl/ether

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3374-88-7

254.31

C13H10N4S

>98% (HPLC)

In Vitro:?DMSO : ≥ 49.5 mg/mL (194.64 m)

N(c1nc(cs1)-c1ccccn1)c1ccccn1

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(-20℃)

With Ice Pack

≥ 2 years