VU591

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VU591是第一个报道的选择性小分子ROMK抑制剂（IC50为0.24 μM）。它抑制离体灌注大鼠集合管中的钾转运，但对钠转运没有影响。

VU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM).?It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.

VU591 is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.

VU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg; Result:Showed antidepressive effect in the tail suspension test (TST).

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Cell Cycle/DNA Damage

Potassium Channel

Kir1.1|ROMK

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1222810-74-3

368.3

C16H12N6O5

>98% (HPLC)

DMSO:60 mg/mL (162.91 mM; Need ultrasonic)

[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

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(-20℃)

With Ice Pack

≥ 2 years