Adarotene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿达罗汀是一种有效的细胞凋亡诱导剂。令人惊讶的是，它会产生 DNA 损伤，并对大量人类肿瘤细胞表现出有效的抗增殖活性。

Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.(In Vitro):Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM . Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium .(In Vivo):Adarotene (30, 40 mg/kg, p.o.) results in a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity . Adarotene (15, 20 mg/kg, p.o.) causes a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in human melanoma, MeWo, growing in nude mice .

Adarotene causes a dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM. Adarotene causes cell accumulation in G1/S or S phase of cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. The molecular target of ST1926 apoptotic activity in myeloid leukemia cells is similar to the ligand-binding domain of RARγ. Adarotene treatment of cells results in rapid accumulation of intracellular calcium.

Adarotene (15, 20 mg/kg, p.o.) causes a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in a human melanoma, MeWo, growing in nude mice. Adarotene (30, 40 mg/kg, p.o.) results in a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity.

ST1926

Apoptosis

Apoptosis

Antibiotic| Bacterial| Fungal| Parasite| Phosphatase

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496868-77-0

374.48

C25H26O3

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (66.76 mM)

OC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2

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(-20℃)

With Ice Pack

≥ 2 years