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α-Zearalenol
CAS No. 36455-72-8
α-Zearalenol ( —— )
产品货号. M26547 CAS No. 36455-72-8
α-玉米赤霉烯醇是玉米赤霉烯酮的主要代谢物之一。 α-玉米赤霉烯醇与雌激素结构相似，因此α-玉米赤霉烯醇可以与雌激素受体（ER）结合。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥5189 | 有现货 |
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| 50MG | ￥7049 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥2432 | 有现货 |
|
生物学信息
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产品名称α-Zearalenol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述α-玉米赤霉烯醇是玉米赤霉烯酮的主要代谢物之一。 α-玉米赤霉烯醇与雌激素结构相似，因此α-玉米赤霉烯醇可以与雌激素受体（ER）结合。
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产品描述α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).(In Vitro):α-Zearalenol is resulted able to induce: (i) an increase of the cell viability on MCF-7 cells mainly after 72?h treatment, (ii) a slight decrease of the cell viability on MDA-MB231 cells, and (iii) an increase of cells in S phase of the cell cycle and of ROS only in MCF-7 cells. Moreover, the evaluation of metabolomics profile evidenced that after treatment with α-zol the levels of some metabolites increased in MCF-7 cells whereas decreased slightly in MDA-MB231 cells.
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体外实验——
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体内实验——
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同义词——
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体Autophagy| RARγ
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研究领域——
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适应症——
化学信息
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CAS Number36455-72-8
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分子量320.385
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分子式C18H24O5
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@H]1CCC[C@H](O)CCC\C=C\c2cc(O)cc(O)c2C(=O)O1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Etienne Thoreau, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1736-1741.
