VU6005649 ( —— )

产品货号. M26504 CAS No. 2137047-43-7

VU6005649 是 CNS 渗透性 mGlu7/8 受体的激动剂（EC50：对于 mGlu7 受体和 mGlu8 受体分别为 0.65 μM 和 2.6 μM）。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥231	有现货
10MG	￥356	有现货
25MG	￥710	有现货
50MG	￥1116	有现货
100MG	￥1719	有现货
200MG	￥2412	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥154	有现货

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生物学信息

产品名称

VU6005649
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

VU6005649 是 CNS 渗透性 mGlu7/8 受体的激动剂（EC50：对于 mGlu7 受体和 mGlu8 受体分别为 0.65 μM 和 2.6 μM）。
产品描述

VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).(In Vitro):VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.(In Vivo):In wild-type mice, VU6005649 shows modest but significant pro-cognitive effects on associative learning and the first example of the efficacy of a mGlu7/8 positive allosteric modulator (PAM) in this model.
体外实验

VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.
体内实验

When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model.
同义词

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通路

Neuroscience
靶点

GluR
受体

——
研究领域

——
适应症

——

化学信息

CAS Number

2137047-43-7
分子量

357.284
分子式

C16H12F5N3O
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 50 mg/mL (139.95 mM)
SMILES

COc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Chen XL, et al. An uncommon plant growth regulator, diethyl aminoethyl hexanoate, is highly effective in tissue cultures of the important medicinal plant purple coneflower (Echinacea purpurea L.). Biomed Res Int. 2013;2013:540316.

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摩尔计算器

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