PQM130

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PQM130 是一种阿魏酰-多奈哌齐杂合化合物，可对抗 Aβ1-42 寡聚物 (AβO) 引起的神经毒性，并具有抗炎活性。 PQM130可用于抗AD研究。

PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies.(In Vitro):PQM130 had already shown anti-inflammatory activity in different in vivo models and neuroprotective activity in human neuronal cells.?(In Vivo):The intracerebroventricular (i.c.v.) injection of AβO in mice caused the increase of memory impairment, oxidative stress, neurodegeneration, and neuroinflammation.?Instead, PQM130 (0.5-1 mg/kg) treatment after the i.c.v. AβO injection reduced oxidative damage and neuroinflammation and induced cell survival and protein synthesis through the modulation of glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinases (ERK1/2).?Moreover, PQM130 increased brain plasticity and protected mice against the decline in spatial cognition.?PQM130 modulated different pathways compared to donepezil, and it is much more effective in counteracting AβO damage.?

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PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) . Animal Model:Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) .Dosage:0.5 and 1.0 mg/kg.Administration:IP injection daily for 10 days.Result:Ameliorated Aβ1-42O-induced cognitive deficits in mice.Prevented Aβ1-42O-induced neuronal death in mice.Antagonized Aβ1-42O-Induced Oxidative Stress in Mice.Regulated GSK3β and ERK1/2 protein expressions in mice.Reduced Aβ1-42O-induced astrocytic activation in mice.

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Membrane Transporter/Ion Channel

Beta Amyloid

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2089415-51-8

381.472

C23H27NO4

>98% (HPLC)

In Vitro:?DMSO : 1.82 mg/mL (4.77 mM)

COc1cc(\C=C\C(=O)OCC2CCN(Cc3ccccc3)CC2)ccc1O

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(-20℃)

With Ice Pack

≥ 2 years