KIN101

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KIN101 是 IRF-3 依赖性信号传导的异黄酮激动剂，可诱导 IRF-3 核转位。 KIN101 对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。

KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.(In Vitro):KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.

KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance.KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels.KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells.KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV). Western Blot Analysis Cell Line:MRC5 cells Concentration:10 μM Incubation Time:24 hours Result:Caused a significant decrease in the NP protein abundance. RT-PCR Cell Line:Huh7 cells Concentration:10 μM Incubation Time:18 hours Result:Showed a >1 log decrease in HCV RNA levels.

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3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene

Microbiology/Virology

HCV

NMDA

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610753-87-2

395.22

C16H11BrO5S

>98% (HPLC)

In Vitro:?DMSO : 41.67 mg/mL (105.43 mM)

CS(=O)(=O)Oc1ccc2c(c1)occ(-c1ccc(Br)cc1)c2=O

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(-20℃)

With Ice Pack

≥ 2 years