Ibiglustat (L-Malic acid)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ibiglustat（L-苹果酸）是一种选择性、脑渗透性、葡萄糖基神经酰胺合酶变构抑制剂。

Ibiglustat (L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s.(In Vitro):Ibiglustat (L-Malic acid) (1 μM) treated Fabry disease cells are close to the physiological level in untreated WT cells in GL-3 levels. Ibiglustat (L-Malic acid) prevents additional GL-3 accumulation and ameliorates the abundant GL-3 levels in FD cardiomyocytes.

Ibiglustat (SAR402671) (1 μM, 15 days) L-Malic acid treated Fabry disease (FD) cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat L-Malic acid can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes.

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Ibiglustat L-Malic acid | Venglustat (L-Malic acid) | SAR402671 (L-Malic acid) | GZ402671 (L-Malic acid)

Metabolic Enzyme/Protease

Transferase

tubulin polymerization

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1629063-78-0

523.57

C24H30FN3O7S

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (191.00 mM)

[C@H](CC(O)=O)(C(O)=O)O.C(NC(O[C@H]1C2CCN(C1)CC2)=O)(C)(C)C=3N=C(SC3)C4=CC=C(F)C=C4

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(-20℃)

With Ice Pack

≥ 2 years