Endoxifen (E-isomer)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Endoxifen E-isomer (E-Endoxifen) 是 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质。Endoxifen E-isomer 具有抗雌激素作用。

Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.(In Vitro):Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser-known (E)-isomer. (E)-Endoxifen is identified as the primary degradant. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions.

Endoxifen E-isomer (1-1000 nM; 12 h) inhibits PGR gene expression in E2-induced MCF-7 cells.

——

E-Endoxifen | Endoxifen E-isomer

Endocrinology/Hormones

Estrogen Receptor/ERR

PEGs

——

——

114828-90-9

373.49

C25H27NO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (133.87 mM)

OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1

——

(-20℃)

With Ice Pack

≥ 2 years