CHK1-IN-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CHK1-IN-2 是检查点激酶 1 的抑制剂 (CHK1；IC50: 0.4 nM)。

CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).(In Vitro):CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 μM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM).(In Vivo):In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected.

CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displays low affinity for hERG (IC50 > 40 μM).

CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected.

——

Angiogenesis

Chk

Alkyl-Chain

——

——

2097252-39-4

405.466

C20H23N9O

>98% (HPLC)

——

CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C)c1

——

(-20℃)

With Ice Pack

≥ 2 years