021-51111890
购物车（）
sales@molnova.cn
Ca2+ channel agonist 1
CAS No. 1402821-24-2
Ca2+ channel agonist 1 ( —— )
产品货号. M26083 CAS No. 1402821-24-2
Ca2+ 通道激动剂 1 是 N 型 Ca2+ 通道的激动剂和 Cdk2 的抑制剂（EC50：14.23 μM 和 3.34 μM），可用作运动神经末梢功能障碍的潜在治疗方法。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1644 | 有现货 |
|
| 10MG | ￥2366 | 有现货 |
|
| 25MG | ￥3646 | 有现货 |
|
| 50MG | ￥4976 | 有现货 |
|
| 100MG | ￥6588 | 有现货 |
|
| 200MG | ￥8892 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1321 | 有现货 |
|
生物学信息
-
产品名称Ca2+ channel agonist 1
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Ca2+ 通道激动剂 1 是 N 型 Ca2+ 通道的激动剂和 Cdk2 的抑制剂（EC50：14.23 μM 和 3.34 μM），可用作运动神经末梢功能障碍的潜在治疗方法。
-
产品描述Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.(In Vitro):Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
-
体外实验Ca2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
-
体内实验——
-
同义词——
-
通路GPCR/G Protein
-
靶点Calcium Channel
-
受体Apoptosis| NF-κB
-
研究领域——
-
适应症——
化学信息
-
CAS Number1402821-24-2
-
分子量354.458
-
分子式C19H26N6O
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 50 mg/mL (141.06 mM)
-
SMILESCCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul). 2014 Jan;22(1):55-61.
产品手册
关联产品
-
Stugeron
Cinnarizine 是哌嗪的化合物衍生物，具有抗组胺剂和钙通道阻滞剂的作用。
-
MMK 1
Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
-
Imagabalin
Imagabalin (PD 0332334) 是电压依赖性钙通道 (VDCC) α2δ 亚基的新型配体，对 α2δ1 亚基比 α2δ2 具有一定选择性。
