Sal003 ( SAL-003 | SAL 003 | SAL003 )

产品货号. M17162 CAS No. 1164470-53-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Sal003
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Sal003 是一种有效的细胞渗透性类似物，可抑制 eIF2α 磷酸酶。
产品描述

SAL-003 is a cell-permeable inhibitor of eIF2α dephosphorylation. SAL003 is an Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Sal003?mediated upregulation of eIF2α phosphorylation suppressed cisplatin?induced p53 activation. Furthermore, reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis.
体外实验

Apoptosis Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1 hour Result:Phosphorylated eIF2α and thus enhanced SubAB-induced apoptotic signaling.Western Blot Analysis Cell Line:Mouse embryonic fibroblasts (MEFs)Concentration:20 μM Incubation Time:1 hour, 3 hours, 6 hours, 12 hours Result:Sharply increased eIF2α phosphorylation in mouse MEFs.
体内实验

Animal Model:Rats (300-325g)Dosage:20 μM Administration:Intrahippocampal injection; 8 minutes Result:Impaired contextual memory.
同义词

SAL-003 | SAL 003 | SAL003
通路

GPCR/G Protein
靶点

Calcium Channel
受体

eIF-2α phosphatase
研究领域

Cancer
适应症

——

CAS Number

1164470-53-4
分子量

463.21
分子式

C18H15Cl4N3OS
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 100 mg/mL 215.88 mM
SMILES

c1ccc(cc1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc1ccc(cc1)Cl
化学全称

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

1. Robert F, et al. Mol Biol Cell. 2006, 17(11), 4632-4644.

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