AZ-23

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZ-23 是 ATP 竞争性和 Trk 激酶 A/B/C 的抑制剂。

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.

AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma.

AZ23 | AZ 23

Tyrosine Kinase

Trk Receptor

TrkA|TrkB

——

——

915720-21-7

391.83

C17H19ClFN7O

>98% (HPLC)

DMSO:125 mg/mL (319.02 mM; Need ultrasonic)

CC(C)Oc1n[nH]c(Nc(nc(N[C@@H](C)c(cc2)ncc2F)nc2)c2Cl)c1

——

(-20℃)

With Ice Pack

≥ 2 years