CH7057288

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CH7057288 是一种有效的选择性 TRK 抑制剂，对 TRKA、TRKB 和 TRKC 的 IC50 值分别为 1.1 nM、7.8 nM 和 5.1 nM。

CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM 7.8 nM and 5.1 nM for TRKA TRKB and TRKC respectively.

CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer.

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Tyrosine Kinase

Trk Receptor

Trk

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2095616-82-1

569.67

C32H31N3O5S

>98% (HPLC)

DMSO:34 mg/mL (59.68 mM)

Cc1cc(cc(n1)C#Cc1ccc2c3c(oc2c1)C(C)(C)c1cc(NS(C)(=O)=O)ccc1C3=O)C(=O)NC(C)(C)C

N-(tert-butyl)-2-((66-dimethyl-8-(methylsulfonamido)-11-oxo-611-dihydronaphtho[23-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide

(-20℃)

With Ice Pack

≥ 2 years