2-Iminobiotin hydrobromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2-Iminobiotin Hydrobromide 是一种生物素的环状胍基类似物，可作为诱导型一氧化氮合酶 (iNOS) 和神经元 NOS（nNOS；小鼠 iNOS 和大鼠 nNOS 的 Ki 值分别为 21.8 和 37.5 μM）的可逆抑制剂。

2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS;?Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).(In Vitro):Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.

Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.

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Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE

Immunology/Inflammation

NOS

iNOS|nNOS|NOS

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76985-52-9

324.24

C10H18BrN3O2S

>98% (HPLC)

DMSO:12.5 mg/mL (51.37 mM)

[H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br

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(-20℃)

With Ice Pack

≥ 2 years