D-Glutamic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

D-谷氨酸是L-谷氨酸的对映体，广泛应用于医药和食品领域。

D-glutamic acid, the enantiomer of L-glutamic acid, is widely used in medicine and food.

Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens.

D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid.

(R)-Glutamic acid

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

——

——

6893-26-1

147.13

C5H9NO4

>98% (HPLC)

H2O:10 mg/mL (67.97 mM; Need ultrasonic)

N[C@H](CCC(O)=O)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years